abstract：BACKGROUND:Adiponectin and resistin are recently discovered adipokines that may provide a molecular link between adiposity and type 2 diabetes. OBJECTIVE:To evaluate whether total and high-molecular-weight adiponectin and resistin are associated with future risk for type 2 diabetes, independent of obesity and other kn...

journal_title：Annals of internal medicine

authors： Heidemann C,Sun Q,van Dam RM,Meigs JB,Zhang C,Tworoger SS,Mantzoros CS,Hu FB

更新日期：2008-09-02 00:00:00

abstract：BACKGROUND:Combining endoscopic therapy and beta-blockers may improve outcomes in patients with cirrhosis and bleeding esophageal varices. PURPOSE:To assess whether a combination of endoscopic and drug therapy prevents overall and variceal rebleeding and improves survival better than either therapy alone. DATA SOURCE...

journal_title：Annals of internal medicine

authors： Gonzalez R,Zamora J,Gomez-Camarero J,Molinero LM,Bañares R,Albillos A

更新日期：2008-07-15 00:00:00

abstract：BACKGROUND:Although HIV infection is more prevalent in people younger than age 45 years, a substantial number of infections occur in older persons. Recent guidelines recommend HIV screening in patients age 13 to 64 years. The cost-effectiveness of HIV screening in patients age 55 to 75 years is uncertain. OBJECTIVE:To...

journal_title：Annals of internal medicine

authors： Sanders GD,Bayoumi AM,Holodniy M,Owens DK

更新日期：2008-06-17 00:00:00

abstract：DESCRIPTION:Updated U.S. Preventive Services Task Force (USPSTF) recommendation about screening for type 2 diabetes mellitus in adults. METHODS:To estimate the balance of benefits and harms of screening, the USPSTF updated its 2003 evidence review, adding evidence from new trials as well as updates on earlier studies....

journal_title：Annals of internal medicine

authors： U.S. Preventive Services Task Force.

更新日期：2008-06-03 00:00:00

abstract：:Systematic reviewers increasingly must decide whether and how to incorporate existing systematic reviews into complex systematic reviews that are commissioned to support clinical guideline development or for other health policy uses. To date, however, this issue has been largely unexamined. Reviewers seeking to incorp...

journal_title：Annals of internal medicine

authors： Whitlock EP,Lin JS,Chou R,Shekelle P,Robinson KA

更新日期：2008-05-20 00:00:00

abstract：BACKGROUND:A sensitive and acceptable screening regimen for women at high risk for breast cancer is essential. Contrast-enhanced magnetic resonance imaging (MRI) of the breast is highly sensitive for diagnosis of breast cancer but has variable specificity. PURPOSE:To summarize the sensitivity, specificity, likelihood ...

journal_title：Annals of internal medicine

authors： Warner E,Messersmith H,Causer P,Eisen A,Shumak R,Plewes D

更新日期：2008-05-06 00:00:00

abstract：:Smoking remains the leading cause of preventable death in the United States, yet it is still regarded by many as merely a bad habit. Most smokers want to quit but find it difficult. Behavioral counseling and pharmacotherapies are available, safe, and effective in the treatment of tobacco dependence. Nicotine replaceme...

journal_title：Annals of internal medicine

authors： Steinberg MB,Schmelzer AC,Richardson DL,Foulds J

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:Lack of confidence in postpolypectomy surveillance guidelines may be a factor in the observed low adherence rates among providers. OBJECTIVE:To assess the 2006 postpolypectomy colonoscopy surveillance guidelines, which recommend 3-year follow-up colonoscopy for individuals with high-risk adenomas (defined a...

journal_title：Annals of internal medicine

authors： Laiyemo AO,Murphy G,Albert PS,Sansbury LB,Wang Z,Cross AJ,Marcus PM,Caan B,Marshall JR,Lance P,Paskett ED,Weissfeld J,Slattery ML,Burt R,Iber F,Shike M,Kikendall JW,Lanza E,Schatzkin A

更新日期：2008-03-18 00:00:00

abstract：BACKGROUND:Although several agents are available to treat osteoporosis, the relative efficacy and toxicity of these agents when used to prevent fractures has not been well described. PURPOSE:To compare the benefits in fracture reduction and the harms from adverse events of various therapies for osteoporosis. DATA SOU...

journal_title：Annals of internal medicine

authors： MacLean C,Newberry S,Maglione M,McMahon M,Ranganath V,Suttorp M,Mojica W,Timmer M,Alexander A,McNamara M,Desai SB,Zhou A,Chen S,Carter J,Tringale C,Valentine D,Johnsen B,Grossman J

更新日期：2008-02-05 00:00:00

abstract：BACKGROUND:The comparative effectiveness of rheumatoid arthritis therapies is uncertain. PURPOSE:To compare the benefits and harms of disease-modifying antirheumatic drugs (DMARDs) for adults with rheumatoid arthritis. DATA SOURCES:Records limited to the English language and studies of adults were identified by using...

journal_title：Annals of internal medicine

authors： Donahue KE,Gartlehner G,Jonas DE,Lux LJ,Thieda P,Jonas BL,Hansen RA,Morgan LC,Lohr KN

更新日期：2008-01-15 00:00:00

abstract：BACKGROUND:The long-term risk for fatal pulmonary embolism (PE) after treatment of venous thromboembolism (VTE) may be an important factor in the decision to discontinue this treatment. OBJECTIVE:To provide reliable and precise estimates of the annual risk for fatal PE and the case-fatality rate of disease recurrence ...

journal_title：Annals of internal medicine

authors： Douketis JD,Gu CS,Schulman S,Ghirarduzzi A,Pengo V,Prandoni P

更新日期：2007-12-04 00:00:00

abstract：BACKGROUND:Short-term aspirin therapy can lower the risk for venous thromboembolism (VTE) in high-risk patients, but whether the long-term use of low-dose aspirin reduces risk in healthy adults is uncertain. OBJECTIVE:To test the efficacy of long-term aspirin therapy for preventing VTE. DESIGN:Secondary analysis of a...

journal_title：Annals of internal medicine

authors： Glynn RJ,Ridker PM,Goldhaber SZ,Buring JE

更新日期：2007-10-16 00:00:00

abstract：:A recent, widely publicized meta-analysis of 42 clinical trials concluded that rosiglitazone was associated with an approximately 43% increased risk for myocardial infarction and an approximately 64% increased risk for cardiovascular death. The sensitivity of these conclusions to several methodological choices was not...

journal_title：Annals of internal medicine

authors： Diamond GA,Bax L,Kaul S

更新日期：2007-10-16 00:00:00

abstract：BACKGROUND:Many nonpharmacologic therapies are available for treatment of low back pain. PURPOSE:To assess benefits and harms of acupuncture, back schools, psychological therapies, exercise therapy, functional restoration, interdisciplinary therapy, massage, physical therapies (interferential therapy, low-level laser ...

journal_title：Annals of internal medicine

authors： Chou R,Huffman LH,American Pain Society.,American College of Physicians.

更新日期：2007-10-02 00:00:00

abstract：BACKGROUND:Certain medications are identified by the U.S. Food and Drug Administration (FDA) as class D or X because they increase the risk for birth defects if used during pregnancy. OBJECTIVE:To assess pregnancy rates and the frequency of contraceptive counseling documented with prescriptions for class D or X drugs ...

journal_title：Annals of internal medicine

authors： Schwarz EB,Postlethwaite DA,Hung YY,Armstrong MA

更新日期：2007-09-18 00:00:00

abstract：BACKGROUND:Dietary and lifestyle modification efforts are the primary treatments for people who are obese or overweight. The effect of dietary counseling on long-term weight change is unclear. PURPOSE:To perform a meta-analysis of the effect of dietary counseling compared with usual care on body mass index (BMI) over ...

journal_title：Annals of internal medicine

authors： Dansinger ML,Tatsioni A,Wong JB,Chung M,Balk EM

更新日期：2007-07-03 00:00:00

abstract：BACKGROUND:Advice and exercise are widely recommended for subacute low back pain, but the effectiveness of these interventions is unclear. OBJECTIVE:To investigate the effectiveness of physiotherapist-prescribed exercise, advice, or both for subacute low back pain. DESIGN:Factorial randomized, placebo-controlled tria...

journal_title：Annals of internal medicine

authors： Pengel LH,Refshauge KM,Maher CG,Nicholas MK,Herbert RD,McNair P

更新日期：2007-06-05 00:00:00

abstract：BACKGROUND:Longer-term mortality benefit and cost-effectiveness for abdominal aortic aneurysm (AAA) screening are uncertain. OBJECTIVE:To estimate the benefits, in terms of AAA-related and all-cause mortality, and cost-effectiveness of ultrasonography screening for AAA in a group that was invited to screening compared...

journal_title：Annals of internal medicine

authors： Kim LG,P Scott RA,Ashton HA,Thompson SG,Multicentre Aneurysm Screening Study Group.

更新日期：2007-05-15 00:00:00

abstract：BACKGROUND:Tumor necrosis factor-alpha is present in arteries in giant cell arteritis. OBJECTIVE:To evaluate the efficacy of infliximab, an anti-tumor necrosis factor-alpha agent, in giant cell arteritis. DESIGN:Randomized, controlled trial. SETTING:22 sites in the United States, the United Kingdom, Belgium, Italy, ...

journal_title：Annals of internal medicine

authors： Hoffman GS,Cid MC,Rendt-Zagar KE,Merkel PA,Weyand CM,Stone JH,Salvarani C,Xu W,Visvanathan S,Rahman MU,Infliximab-GCA Study Group.

更新日期：2007-05-01 00:00:00

abstract：:Quality improvement (QI) activities can improve health care but must be conducted ethically. The Hastings Center convened leaders and scholars to address ethical requirements for QI and their relationship to regulations protecting human subjects of research. The group defined QI as systematic, data-guided activities d...

journal_title：Annals of internal medicine

authors： Lynn J,Baily MA,Bottrell M,Jennings B,Levine RJ,Davidoff F,Casarett D,Corrigan J,Fox E,Wynia MK,Agich GJ,O'Kane M,Speroff T,Schyve P,Batalden P,Tunis S,Berlinger N,Cronenwett L,Fitzmaurice JM,Dubler NN,James B

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:Benign reductions in neutrophil counts may be more common at certain ages and in certain ethnic groups and may be affected by sex and smoking status. OBJECTIVE:To determine differences in neutrophil counts in the U.S. population according to ethnicity, age, sex, and smoking status. DESIGN:Population-based,...

journal_title：Annals of internal medicine

authors： Hsieh MM,Everhart JE,Byrd-Holt DD,Tisdale JF,Rodgers GP

更新日期：2007-04-03 00:00:00

abstract：:This guideline summarizes the current approaches for the diagnosis of venous thromboembolism. The importance of early diagnosis to prevent mortality and morbidity associated with venous thromboembolism cannot be overstressed. This field is highly dynamic, however, and new evidence is emerging periodically that may cha...

journal_title：Annals of internal medicine

authors： Qaseem A,Snow V,Barry P,Hornbake ER,Rodnick JE,Tobolic T,Ireland B,Segal JB,Bass EB,Weiss KB,Green L,Owens DK,Joint American Academy of Family Physicians\/American College of Physicians Panel on Deep Venous Thrombosis\/Pulmonary

更新日期：2007-03-20 00:00:00

abstract：BACKGROUND:A survey of general internist members of the American College of Physicians (ACP) in 1986 found that they did a large number and variety of procedures in their practices. Since then, changes in the practice of medicine, regulatory requirements, and availability of subspecialists may have affected the number ...

journal_title：Annals of internal medicine

authors： Wigton RS,Alguire P,American College of Physicians.

更新日期：2007-03-06 00:00:00

abstract：BACKGROUND:Although clinicians avoid giving meropenem to patients with penicillin allergy because of potential cross-reactivity, the rate of cross-reactivity between penicillins and meropenem has not been prospectively determined. OBJECTIVE:To assess the tolerability of meropenem in patients with documented penicillin...

journal_title：Annals of internal medicine

authors： Romano A,Viola M,Guéant-Rodriguez RM,Gaeta F,Valluzzi R,Guéant JL

更新日期：2007-02-20 00:00:00

abstract：BACKGROUND:Home-based primary care for homebound seniors is complex, and practice constraints are unique. No quality-of-care standards exist. OBJECTIVE:To identify process quality indicators that are essential to high-quality, home-based primary care. DESIGN:An expert development panel reviewed established and new qu...

journal_title：Annals of internal medicine

authors： Smith KL,Soriano TA,Boal J

更新日期：2007-02-06 00:00:00

abstract：:Reversible cerebral vasoconstriction syndromes (RCVS) comprise a group of diverse conditions, all characterized by reversible multifocal narrowing of the cerebral arteries heralded by sudden (thunderclap), severe headaches with or without associated neurologic deficits. Reversible cerebral vasoconstriction syndromes a...

journal_title：Annals of internal medicine

authors： Calabrese LH,Dodick DW,Schwedt TJ,Singhal AB

更新日期：2007-01-02 00:00:00

abstract：:Antibiotic-associated diarrhea and colitis were well established soon after antibiotics became available. Early work implicated Staphylococcus aureus, but in 1978 Clostridium difficile became the established pathogen in the vast majority of cases. In the first 5 years (1978 through 1983), the most common cause was cli...

journal_title：Annals of internal medicine

authors： Bartlett JG

更新日期：2006-11-21 00:00:00

abstract：BACKGROUND:Injection insulin therapy is not readily accepted by patients and many health care providers; therefore, less invasive options for insulin therapy are desirable. PURPOSE:To examine the efficacy, safety, and patient acceptability of inhaled insulin therapy in nonpregnant adults with diabetes mellitus. DATA ...

journal_title：Annals of internal medicine

authors： Ceglia L,Lau J,Pittas AG

更新日期：2006-11-07 00:00:00

abstract：BACKGROUND:Health care-associated infections from invasive medical devices in the intensive care unit (ICU) are a major threat to patient safety. Most published studies of ICU-acquired infections have come from industrialized western countries. In a Centers for Disease Control and Prevention (CDC) National Nosocomial I...

journal_title：Annals of internal medicine

authors： Rosenthal VD,Maki DG,Salomao R,Moreno CA,Mehta Y,Higuera F,Cuellar LE,Arikan OA,Abouqal R,Leblebicioglu H,International Nosocomial Infection Control Consortium.

更新日期：2006-10-17 00:00:00

abstract：:Recent national recommendations have proposed that physicians should titrate lipid therapy to achieve low-density lipoprotein (LDL) cholesterol levels less than 1.81 mmol/L (<70 mg/dL) for patients at very high cardiovascular risk and less than 2.59 mmol/L (<100 mg/dL) for patients at high cardiovascular risk. To exam...

journal_title：Annals of internal medicine

authors： Hayward RA,Hofer TP,Vijan S

更新日期：2006-10-03 00:00:00

abstract：BACKGROUND:Many dispensing errors made in hospital pharmacies can harm patients. Some hospitals are investing in bar code technology to reduce these errors, but data about its efficacy are limited. OBJECTIVE:To evaluate whether implementation of bar code technology reduced dispensing errors and potential adverse drug ...

journal_title：Annals of internal medicine

authors： Poon EG,Cina JL,Churchill W,Patel N,Featherstone E,Rothschild JM,Keohane CA,Whittemore AD,Bates DW,Gandhi TK

更新日期：2006-09-19 00:00:00

abstract：BACKGROUND:The risk for hypertension after kidney donation remains uncertain. PURPOSE:To see whether normotensive adults who donate a kidney develop higher blood pressure and risk for hypertension compared with nondonor adults acting as control participants. DATA SOURCES:MEDLINE, EMBASE, and Science Citation Index we...

journal_title：Annals of internal medicine

authors： Boudville N,Prasad GV,Knoll G,Muirhead N,Thiessen-Philbrook H,Yang RC,Rosas-Arellano MP,Housawi A,Garg AX,Donor Nephrectomy Outcomes Research (DONOR) Network.

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:Increased prevalence of adolescent obesity requires effective treatment options beyond behavior therapy. OBJECTIVE:To see whether sibutramine reduced weight more than placebo in obese adolescents who were receiving a behavior therapy program. DESIGN:12-month, 3:1 randomized, double-blind trial conducted fr...

journal_title：Annals of internal medicine

authors： Berkowitz RI,Fujioka K,Daniels SR,Hoppin AG,Owen S,Perry AC,Sothern MS,Renz CL,Pirner MA,Walch JK,Jasinsky O,Hewkin AC,Blakesley VA,Sibutramine Adolescent Study Group.

更新日期：2006-07-18 00:00:00

abstract：:Active-control noninferiority trials are being performed with increasing frequency when standard placebo-controlled trials are considered unethical. Three attributes are optimally required to establish noninferiority: 1) The treatment under consideration exhibits therapeutic noninferiority to the active control; 2) th...

journal_title：Annals of internal medicine

authors： Kaul S,Diamond GA

更新日期：2006-07-04 00:00:00

abstract：:There has been considerable change in the practice of internal medicine in the past quarter century, including the rise of specialization, increasing time pressure, the hospitalist movement, and the rapidly changing responsibilities of internists in inpatient and outpatient settings. Training programs have not adequat...

journal_title：Annals of internal medicine

authors： Association of Program Directors in Internal Medicine.,Fitzgibbons JP,Bordley DR,Berkowitz LR,Miller BW,Henderson MC

更新日期：2006-06-20 00:00:00

abstract：BACKGROUND:Sleep-related accidents often involve healthy young persons who are driving at night. Coffee and napping restore alertness, but no study has compared their effects on real nighttime driving performances. OBJECTIVE:To test the effects of 125 mL of coffee (half a cup) containing 200 mg of caffeine, placebo (d...

journal_title：Annals of internal medicine

authors： Philip P,Taillard J,Moore N,Delord S,Valtat C,Sagaspe P,Bioulac B

更新日期：2006-06-06 00:00:00

abstract：BACKGROUND:Experts consider health information technology key to improving efficiency and quality of health care. PURPOSE:To systematically review evidence on the effect of health information technology on quality, efficiency, and costs of health care. DATA SOURCES:The authors systematically searched the English-lang...

journal_title：Annals of internal medicine

authors： Chaudhry B,Wang J,Wu S,Maglione M,Mojica W,Roth E,Morton SC,Shekelle PG

更新日期：2006-05-16 00:00:00

abstract：BACKGROUND:Progress of diabetes care is a subject of public health concern. OBJECTIVE:To assess changes in quality of diabetes care in the United States by using standardized measures. DESIGN:National population-based, serial cross-sectional surveys. SETTING:National Health and Nutrition Examination Survey (1988-199...

journal_title：Annals of internal medicine

authors： Saaddine JB,Cadwell B,Gregg EW,Engelgau MM,Vinicor F,Imperatore G,Narayan KM

更新日期：2006-04-04 00:00:00

abstract：BACKGROUND:The vast scientific literature on smoking and health contains few large studies with direct estimates of long-term mortality by smoking habits. Data have been lacking, particularly for women. OBJECTIVE:To study smoking and deaths and causes of death in women and men of middle age (40 to 70 years of age). D...

journal_title：Annals of internal medicine

authors： Vollset SE,Tverdal A,Gjessing HK

更新日期：2006-03-21 00:00:00

abstract：BACKGROUND:Rheumatoid arthritis is associated with increased morbidity and mortality because of cardiovascular disease, independent of traditional risk factors. OBJECTIVE:To determine the prevalence of preclinical atherosclerosis in patients with rheumatoid arthritis and to identify clinical and biological markers for...

journal_title：Annals of internal medicine

authors： Roman MJ,Moeller E,Davis A,Paget SA,Crow MK,Lockshin MD,Sammaritano L,Devereux RB,Schwartz JE,Levine DM,Salmon JE

更新日期：2006-02-21 00:00:00